NU7441 (KU-57788)

属性

沸点	~646.9° C at 760 mmHg
熔点	246.28° C
折光率	1.73
溶解性	DMSO 3 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C
密度	1******

描述

应用	A DNA-PK inhibitor, and antitumor agent in vitro.
产品介绍	KU-57788(NU7441)是DNA-PK选择性抑制剂，IC50为14 nM，对mTOR，PI3K，ATM和ATR的抑制性较弱。
生化机理	NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB. NU7441 appreciably increased G(2)-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells .
别名	KU 57788; NU-7441; KU57788; NU7441; NU 7441;8-(4-二苯并噻吩基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮;KU 57788; NU-7441;KU57788;NU7441;NU 7441;8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one