| 产品介绍 |
AZD2461是新型PARP抑制剂，能够避免由Pgp介导的olaparib抗性。 |
| 备注 |
AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1. |
| 生化机理 |
AZD2461 has an 80-fold increased Mdr1b expression on Olaparib-resistant KB1P tumor T6-28, without inhibition of Pgp. AZD2461 induces loss of 53BP1 expression in mice with KB1P tumors with short-term treatment. Long-term AZD2461 treatment is well tolerated and doubled the median relapse-free survival. |
| 别名 |
4-(4-氟-3-((4-甲氧基哌啶-1-基)羰基)苄基)酞嗪-1(2H)-酮;AZD2461;AZD 2461;4-(4-fluoro-3-((4-methoxypiperidin-1-yl)carbonyl)benzyl)phthalazin-1(2h)-one |
