A-803467
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离子通道

A-803467

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  • 阿拉丁
  • 上海
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上海阿拉丁生化科技股份有限公司
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产品特点
规格信息
货号 CAS号
A127941-50mg 944261-79-4
A127941-10mg 944261-79-4
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产品描述

属性

溶解性
  • DMSO 72 mg/mL
  • Water <1 mg/mL
  • Ethanol 11 mg/mL
  • 存贮条件 储存温度-20°C

    描述

    产品介绍 A-803467
    备注 A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM, blocks tetrodotoxin-resistant currents, exhibits >100-fold selectivity against human NaV1.2, NaV1.3, NaV1.5, and NaV1.7.
    生化机理

    A 803467 is a selective Nav1.8 sodium channel blocker and analgesic. A 803467 blocks Nav1.8 with an IC50 of 8 nM and is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. A 803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

    别名 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide;5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
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