产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 产品介绍 | A-803467 |
| 备注 | A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM, blocks tetrodotoxin-resistant currents, exhibits >100-fold selectivity against human NaV1.2, NaV1.3, NaV1.5, and NaV1.7. |
| 生化机理 |
A 803467 is a selective Nav1.8 sodium channel blocker and analgesic. A 803467 blocks Nav1.8 with an IC50 of 8 nM and is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. A 803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models. |
| 别名 | 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide;5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide |
