Vemurafenib (PLX4032, RG7204)

属性

熔点	260-262 °C
溶解性	Soluble in DMSO (100 mg/mL), and methanol. Insoluble in ethanol, and water
存贮条件	储存温度-20°C

描述

应用	A novel and potent inhibitor of B-RAFV600E with IC50 of 31 nM.
产品介绍	Vemurafenib (PLX4032, RG7204)是一种新型有效的B-Raf V600E抑制剂，IC50为31 nM。
备注	Vemurafenib (PLX4032, RG7204) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM.
生化机理	Vemurafenib is a novel and potent inhibitor of B-RAFV600E with IC50 of 31 nM. Has been shown to kill melanoma cells in vitro.
别名	维罗非尼;PLX-4032; RG7204; R7204; RO5185426; PLX4032;N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide