Loratadine

属性

熔点	137°C
溶解性	Soluble in DMSO (50 mg/ml), ethanol (77 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), chloroform, and methanol.
存贮条件	储存温度 2-8°C

描述

应用	A peripheral histamine H1 receptor agonist.
产品介绍	Loratadine是一种选择性的，逆向外周组胺H1受体激动剂，IC50大于32 μM。
备注	Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
生化机理	Loratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Loratadine is a selective inverse peripheral histamine H1-receptor agonist (IC50 > 32 μM).
别名	克敏能;氯雷他定;4-(8-氯-5,6-二氢-11H-苯并[5,6]环庚基[1,2-b]并吡啶-11-烯)-1-哌啶羧酸乙脂;4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester;Loratidine;SCH 29851; SCH29851; SCH-29851

Reaxys-RN	4273483
个人防护设备	Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter
RTECS	TM6129200
WGK德国	2