应用 |
A potent β2-AR agonist. |
产品介绍 |
Formoterol Hemifumarate是一种有效的,选择性的,长效β2-肾上腺素受体激动剂,作用于β2和β1受体,pKd分别为8.12和5.58。 |
备注 |
Formoterol hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist to β2 and β1 receptors with pKd of 8.12 and 5.58, respectively. |
生化机理 |
Formoterol Fumarate is shown to be a potent β-AR adrenoceptor agonist, with a fast onset of effect on the isolated human bronchus model. This compound demonstrates a 330-fold selectivity for β2 over β1 receptors. Formoterol Fumarate has been reported to be 150-200 times more potent than isoprenaline. This agent has also been noted to reduce the loss of muscle mass in murine models. |
别名 |
富马酸福莫特罗; N-[2-羟基-5[(RS)-1-羟基-2-[(RS)-2-(4-甲氧基苯基)-1-甲基乙基胺]乙基]苯基]甲酰胺半富马酸;Foradil;N-[2-Hydroxy-5-[[(1RS)-1-hydroxy-2-[[(1RS)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (E)-2-butenedioate |