| 应用 |
An inhibitor of Cox-1 and Cox-2. |
| 产品介绍 |
(R)-Ibuprofen是ibuprofen的低活性对映体。 |
| 生化机理 |
(R)-Ibuprofen, a nonsteroidal antiinflammatory, is the less active enantiomer of ibuprofen, an inhibitor of Cox-1 and Cox-2. Most of the activity resides in (S)-ibuprofen. It has been observed that the inversion of R(-)-ibuprofen to the S(+) antipode occurs in rat liver but not in either serosal or mucosal sides of the small intestine. (R)-Ibuprofen’s presence can be detected in urine through mass chromatography. A liquid-chromatographic assay has been used to study the pharmacokinetics of the (S)- and (R)-Ibuprofen forms in plasma. |
| 别名 |
(R)-布洛芬;(R)-Ibuprofen;L-Ibuprofen;(alphaR)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid; R-(-)-p-Isobutylhydratropic acid; R-(-)-p-Isobutylhydratropic acid |
