JANEX-1

属性

沸点	468.10° C
熔点	192.17° C
折光率	1.69
溶解性	Soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml).
存贮条件	储存温度-20°C
密度	1.3400

描述

应用	A selective inhibitor of tyrosine kinase activity of JAK3
产品介绍	Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 μM). Janex-1 has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases. Janex-1 acts as a potent inhibitor of glioblastoma cell adhesion and migration and is also reported to block thrombin-induced platelet aggregation.
生化机理	Janex-1是可渗透入细胞的ATP竞争性JAK3特异性抑制剂，对JAK1，JAK2，Zap/Syk和SRC无活性。
别名	WHI-P131;WHI-P 131;4-(4'-羟基苯基)氨基-6,7-二甲氧基喹唑啉;WHI-P131;WHI-P 131;4-(4'-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline