产品描述
| 沸点 | 468.10° C |
| 熔点 | 192.17° C |
| 折光率 | 1.69 |
| 溶解性 | Soluble in DMSO (~1 mg/ml), and DMF (~1 mg/ml). |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.3400 |
| 应用 | A selective inhibitor of tyrosine kinase activity of JAK3 |
| 产品介绍 | Janex-1 is a cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 μM). Janex-1 has no effect on JAK1, JAK2, or Zap/Syk or SRC tyrosine kinases. Janex-1 acts as a potent inhibitor of glioblastoma cell adhesion and migration and is also reported to block thrombin-induced platelet aggregation. |
| 生化机理 | Janex-1是可渗透入细胞的ATP竞争性JAK3特异性抑制剂，对JAK1，JAK2，Zap/Syk和SRC无活性。 |
| 别名 | WHI-P131;WHI-P 131;4-(4'-羟基苯基)氨基-6,7-二甲氧基喹唑啉;WHI-P131;WHI-P 131;4-(4'-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline |
