货号 | CAS号 |
---|---|
H126738-10mg | 349085-38-7 |
H126738-1g | 349085-38-7 |
H126738-250mg | 349085-38-7 |
H126738-50mg | 349085-38-7 |
沸点 | 650.65° C |
熔点 | 221-223° C |
折光率 | 1.65 |
溶解性 |
|
密度 | 1.3300 |
应用 | A potent and selective TRPA1 inhibitor |
产品介绍 | HC-030031是TRPA1通道阻断剂,能拮抗AITC和福尔马林诱发的钙流,IC50分别为6.2 μM和5.3 μM。 |
生化机理 | HC-030031 is a substituted theophylline derivative. Potent and selective ANKTM1 (TRPA1) inhibitor. It antagonizes allyl isothiocyanate (AITC)- and formalin-evoked calcium influx with IC50 values of 6.2 and 5.3 μM respectively. Both inward and outward currents elicited by AITC or formalin are rapidly and reversibly blocked by HC-030031 which also blocks the activation of TRPA1 by N-methylmaleimide and by electrophillic prostaglandins2. TRPV1, TRPV3, TRPV4, hERG and NaV1.2 are not blocked. |
别名 | HC 030031;HC030031; 1,2,3,6-四氢-1,3-二甲基-N-(4-(1-甲基乙基)苯基)-2,6-二氧代-7H-嘌呤-7-乙酰胺;;HC 030031;HC030031; 1,2,3,6-Tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide ;2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide |