应用 |
A macrolide antibiotic with immunosuppresive activity. |
产品介绍 |
Elaiophylin大环内脂类抗菌素,作用于恶性疟原虫K1a 和布氏布锥虫GUTat 3.1 品系,具有抗原生动物活性,IC50分别为370 ng/mL和460 ng/mL。 |
备注 |
Elaiophylin shows antiprotozoal activity against Plasmodium falciparum K1a and Trypanosoma brucei brucei GUTat 3.1 strains with IC50 of 0.36 μM and 0.45 μM, respectively. |
生化机理 |
Elaiophylin is a highly characteristic macrolide antibiotic that was first isolated from a culture of Streptomyces melanosporus. Elaiophylin demonstrates antifungal activity when combined with metabolite rapamycin. Elaiophylin shows shown cytotoxicity against mammalian tumor cells, protozoa, nematodes and antibacterial activity aganst gram-positive bacteria. The compound has also displayed immunosuppressive activity through inhibition of B-cell stimulation and inhibiting proliferation of lymphocytes stimulated by mitogens. Elaiophylin has been found to have antihelminthic to inhibit nitric oxide synthesis. Elaiophylin is an inhibitor of 5 α-Reductase and NOS. |
别名 |
洋橄榄叶素;Azalomycin-B; Gopalamicin; Salbomycin; |