GSK2334470

属性

溶解性	DMSO 90 mg/mL Water <1 mg/mL Ethanol 90 mg/mL
存贮条件	储存温度-20°C

描述

应用	A potent and selective PDK1 inhibitor that subsequently induces apoptotic cell death
产品介绍	GSK2334470是PDK1抑制剂，IC50为10 nM，对别的相关AGC激酶无活性。
生化机理	GSK2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1). GSK2334470 can be used in cells to ablate T-loop phosphorylation and activate SGK, S6K1 and RSK as well as suppress the activation of Akt.
别名	GSK 2334470;GSK-2334470;GSK 2334470;GSK-2334470;(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide