GSK1059615

属性

折光率	1.76
溶解性	DMSO 2 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度2-8℃
密度	1.4400

描述

应用	A potent inhibitor of PI 3-kinase and FRAP (mTOR)
产品介绍	GSK1059615是可逆的PI3Kα/β/δ/γ和mTOR双重抑制剂，IC50为0.4 nM/0.6 nM/2 nM/5 nM和12 nM。
生化机理	GSK 1059615, a pyridinylquinoline derivative, is a novel, ATP-competitive, and reversible class I PI 3-kinase inhibitor. GSK 1059615 inhibits PI 3-kinase signaling and induces G1 arrest and apoptosis, especially in breast tumor cells. GSK 1059615 inhibits PI 3-kinase α (IC50 of 2 nM, Ki of 0.42 nM), β (Ki of 0.6 nM), γ (Ki of 0.47 nM) and δ (Ki of 1.7 nM). GSK 1059615 is also an inhibitor of mTOR (FRAP) (IC50 of 0.4-12 nM).
别名	GSK 1059615; GSK-1059615; (5Z)-5-((4-(4-吡啶基)-6-喹啉基)亚甲基)-2,4-噻唑烷二酮;;GSK 1059615;GSK-1059615;(5z)-5-((4-(4-pyridinyl)-6-quinolinyl)methylene)-2,4-thiazolidinedione