T Cell Receptor 信号通路图

The  T Cell Receptor plays a key role in the immune system. The specificity  of the receptor is governed by the binding site formed from the mature  alpha and beta chains (shown here) or gamma and delta chains in  gamma/delta T Cells. It is the ability of this receptor to bind a  complex of foreign peptide in the groove of an MHC molecule that leads  to T cell activation. Upon activation the T cell can assist in  activating other cells or carry out cytolytic attacks depending on the  particular T cell type. The CD3 complex and CD4 (Th cells) or CD8 (Tc  cells) work to transmit the activation signal to the T cell''s  transcriptional machinary upon engagement of the receptor.   本信号转导涉及的信号分子主要包括：
TCR，CD30，Zap-70，LAF-1，Actinin，Talin，SOS，GRB2，LAT，PLCγ1，NCK，SLP76，ADAP，Vav，WASP，Rac，cdc42，DIgh1，CD4，CD45，CD28，Lck，PI3K，CaM，Calclneurin，CaMKIV，Calpain，IP3R，PIP2，DAG，RasGRP，Ras，Raf，MEK1，MEK2，Erk1，Erk2，CREB，NFAT，TAK1，MEKK1，MKK4，MKK7，JNK，JNK2，MAPK，P38，PDK1，PKCθ，c-Cbl，mMALT1，Bcl10，Carma1，TAK1，IKK，Rel，IκB，NF-κB，mTORC1，Fos，Jun等。