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PPP2R2a基因编码的功能和结构描述

2022.8.22
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zhaoqisun

致力于为分析测试行业奉献终身

该基因产物属于磷酸酶2调节亚基b家族。蛋白磷酸酶2是四种主要的ser/thr磷酸酶之一,与细胞生长和分裂的负调控有关。它由一种常见的异聚核心酶组成,由一个催化亚基和一个恒定的调节亚基组成,与多种调节亚基相结合。b调节亚基可能调节底物的选择性和催化活性。该基因编码调节亚单位b55亚家族的α亚型。另外,已经描述了剪接转录变体。

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described.

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