产品描述
DescriptionChemokines are a large family of small secreted proteins that regulate migration of white blood cells. Based on the arrangement of the first two of the four conserved cysteine residues, chemokines are classified into four subfamilies, CXC, CC, C and recently identified CX3C (1). The CC chemokines, in which the first 2 cysteines are adjacent, usually act on monocytes, T lymphocytes, and, in some cases, eosinophils, basophils, or mast cells. The CC subfamily proteins are 70 to 100 amino acids long, have 25 to 75% identity with each other, and include novel member of the CC chemokine subfamily, designated ABCD1 (SCYA22). The ABCD1 shares 28 to 34% identity with other CC chemokines and contains the characteristic 4-cysteine motif and 9 other highly conserved residues (2). The activated T cell-attracting CC chemokine CCL22 is expressed by stimulated B cells and mature dendritic cells (DC). Both identical and distinct proteins contribute to expression of CCL22 in DC and B cells (3).
Recommended Applications
WB, IHC
Applications and Recommended Dilution FactorsWB: 1:1,000 - 10,000 (5ng)
IHC: 1:100 - 250
Species Reactivity
Mouse
Species cross-reactivity is based on WB analysis.
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Specificity
A synthetic peptide corresponding to residues in mouse ABCD1 was used as an immunogen.
Storage Condition and Buffer
Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
Ccl22 antibody, ABCD-1 antibody, DCBCK antibody, MDC antibody, Scya22 antibody, C-C motif chemokine 22 antibody, Activated B and dendritic cell-derived antibody, CC chemokine ABCD-1 antibody, Small-inducible cytokine A22 antibody
Description References
1. Nomiyama H, et al. Cytogenetics and Cell Genetics 81:10-11, 1998.
2. Godiska R, et al. J Exp Med 185(9):1595-604, 1997.
3. Ghadially H, et al. J Immunol 174(9):5620-9, 2005.
