ACVR1B antibody
Cat.#: 3521-1
Rabbit Monoclonal Antibody
Clone ID: EPR4816
Swiss Prot: P36896
Mol Weight: 52kDa
Size: 100ul

Description
ACVR1B is an activin A type IB receptor. Activins are dimeric growth and differentiation factors that belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases, which include at least two type I and two type II receptors. ACVR1B is a type I receptor that is essential for signaling. Mutations in this protein are associated with pituitary tumors.

Recommended Applications
WB, FC

Applications and Recommended Dilution Factors
WB: 1:10,000-50,000
FC: 1:10 - 100

Species Reactivity
Human, Mouse, Rat

Species cross-reactivity is based on WB analysis

Products Data 

 

Western blot analysis on (A) HepG2, (B) SH-SY5Y, (C) U87-MG, and (D) 293T cell lysates using anti-ACVR1B RabMAb (cat. #3521-1).
Flow cytometric analysis of permeabilized 293T cells using anti-ACVR1B RabMAb (red) (catalog # 3521-1) or a rabbit IgG (negative) (green).

Specificity
A synthetic peptide corresponding to residues in the intracellular domain of human ACVR1B was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
ACVR1B antibody, ACTRIB antibody, ACVRLK4 antibody, ALK4 antibody, SKR2 antibody, Activin receptor type-1B antibody, Serine/threonine-protein kinase receptor R2 antibody

Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.