ACE2 antibody
Cat.#: 3583-1
Rabbit Monoclonal Antibody

Clone ID: EPR4435(2)
Swiss Prot: Q9BYF1
Mol Weight: 110kDa
Size: 100ul

Description
ACE2 belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of ACE2 suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, it is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63 (1).

Recommended Applications
WB, IHC, ICC, IP

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:100 - 250
ICC: 1:50 - 100
IP: 1:10 - 100

Species Reactivity
Human, Mouse, Rat

Mouse cross reactivity tested by western blot and IHC
Rat cross reactivity tested by western blot only

Products Data  

 

Western blot analysis on (A) fetal kidney and (B) human testis lysates using anti-ACE2 RabMAb (cat. #3583-1).
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ACE2 RabMAb (cat. #3583-1).
Immunohistochemical analysis of paraffin-embedded human testis tissue using anti-ACE2 RabMAb (cat. #3583-1).

Specificity
A synthetic peptide corresponding to residues in the extracellular domain of human ACE2 was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
ACE2 antibody, ACEH antibody, DKFZp434A014 antibody, Processed angiotensin-converting enzyme 2 antibody, Metalloprotease MPROT15 antibody

Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.