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A potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF-1R, IC50=6 nM). It efficiently blocks IGF-1R activity, reduces pAKT and pERK1/2, induces apoptosis in IGF-1R-positive tumor cells and causes complete tumor regression in xenografted and allografted mice. Picropodophyllin downregulates IGF-1R by interfering with the action of β-arrestin 1/MDM2. It causes tumor regression and attenuates invasiveness of uveal melanoma cells. It displays beneficial effects on tumor growth, angiogenesis, bone disease and survival in a mouse multiple myeloma model.
It attenuates intimal hyperplasia after vascular injury. Inhibition of IGF-1R is non-competitive with ATP.
Product Specification
Formula: C22H22O8
MW: 414.4
Purity: ≥98% (TLC)
Appearance: White solid
CAS: 477-47-4
Solubility: Soluble in DMSO (10mg/ml, warm) or dimethyl formamide (25mg/ml)
Shipping: AMBIENT
Long Term Storage: -20°C