溶解性 | Soluble in ethanol (100 mM), DMSO (40 mg/ml), DMF (~15 mg/ml), and Ethanol : PBS (1:1) (~0.5 mg/ml) |
存贮条件 | 储存温度2-8°C |
应用 | An aminophenylpropanoate agonist at the GRP40/FFA1 receptor. |
产品介绍 | GW9508是一种有效的,选择性FFA1(GPR40)激动剂,pEC50为7.32,比作用于GPR120选择性高100倍,以葡萄糖敏感性方式刺激胰岛素的分泌。 |
备注 | GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner. |
生化机理 | GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ~50 nM) with reduced activity towards family members GRP120 (EC50 ~3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors. GW 9508 has been shown to induce GPR40-dependent Ca2+ mobilization in HEK 293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. |
别名 | 4-[[(3-苯氧基苯基)甲基]氨基]苯丙酸;GW 9508;GW-9508;3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid; GPR40 Agonist;4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid |