产品描述
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in water (<1 mg/ml at 25 °C), DMSO (122 mg/ml at 25 °C), methanol, DMF (~30 mg/ml), and ethanol (4 mg/ml at 25 °C). |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | An angiotensin II receptor antagonist. |
| 产品介绍 | Candesartan Cilexetil一种特异性的，非肽类血管生成素II受体（ATR）拮抗剂，也是Candesartan的前体药物，是ATR拮抗剂，IC50为15 μg/kg。 |
| 备注 | Candesartan Cilexetil is a specific nonpeptide Ang II receptor (ATR) antagonist and the prodrug of candesartan which is an ATR antagonist with an IC50 of 15 μg/kg |
| 生化机理 | Candesartan Celexetil Ester is an ester analog of the angiotensin II antagonist Candesartan . Antagonism of this receptor prevents the binding of angiotensin II, a potent vasoconstrictor. This has the overall effect of vasodilation and an increased capillary blood volume. Candesartan Celexetil Ester is an inhibitor of AT1. |
| 别名 | 坎地沙坦酯;2-乙氧基-1-[[2'-(1H-四氮唑-5-基)[1,1'-联苯基]-4-基]甲基]-1H-苯并咪唑-7-甲酸-1-[[(环己氧基)羰基]氧基]乙酯;坎地沙坦西来替昔酯;TCV116;2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-Benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester;TCV 116;TCY 116;TCV-116; TCV116; Atacand |
