产品描述
| 溶解性 |
Soluble in ethanol (22 mg/ml at 25 °C), chloroform, and DMSO (22 mg/ml at 25 °C). Insoluble in water, , , |
| 存贮条件 | 储存温度2-8℃ |
| 应用 | An prohormone neurosteroid also a precursor to gonadal steroid hormones and the adrenal corticosteroids. |
| 产品介绍 | Pregnenolone is an endogenous neurosteroid that is involved in the steroidogenesis of progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens, making it a prohormone. It has been observed to inhibit GABA-gated chloride currents by enhancing receptor desensitization. Pregnenolone is an inhibitor of GABA Receptor and an activator of PXR. |
| 备注 | Pregnenolone is an endogenous steroid hormone for inhibition of M1 receptor- and M3 receptor-mediated currents with IC50 of 11.4 ?M and 6.0 ?M, respectively. |
| 生化机理 | One of a small number of "neurosteroids," steroids synthesized in the brain rather than peripheral sources. Decreased levels of these neurosteroids has been implicated in rodent cognitive decline with age, but studies in humans have been contradictory. |
| 别名 | 孕甾烯醇酮;3β-羟基孕甾-5-烯-20-酮;5-Pregnen-3β-ol-20-one;3β-Hydroxy-5-pregnen-20-one;Arthenolone; Skinostelon; Enelone; Pregnetan; Pregneton;Prenolon; Regnosone |
