产品描述
| 溶解性 | Soluble in water (<1 mg/ml at 25 °C), DMSO (83 mg/ml at 25 °C), methanol, Aqueous Alkali, and ethanol (83 mg/ml at 25 °C). |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | An inhibitor of the angiotensin- coverting enzyme (ACE). |
| 产品介绍 | Ramipril 是血管紧张素转换酶(ACE)抑制剂，IC50为5 nM。 |
| 备注 | Ramipril (Altace) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM. |
| 生化机理 | Ramipril is an inhibitor of the ACE (angiotensin- converting enzyme) that is reported to quickly hydrolyze into the active metabolite Ramiprilat. Studies indicate that Ramipril is a more potent inhibitor in comparison to Zofenopril. Acute coronary syndrome investigations demonstrate that Ramipril increases IL-10, and decreases the levels of MCP-1 and IL-18. |
| 别名 | 雷米普利; N-[1(S)-乙氧羰基-3-苯丙基]-(S)-丙氨酰基-顺桥-2-氮杂二环[3,3,0]辛烷-3(S)-羧酸;(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(乙氧羰基)-3-苯丙基]氨基]-1-氧代丙基]八氢环戊并[b]吡咯-2-羧酸;Tritace;[2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid |
