产品描述
| 沸点 | 657.60° C at 760 mmHg |
| 折光率 | 1.63 |
| 溶解性 | DMSO > 25 mg/ml Ethanol > 25 mg/ml |
| 存贮条件 | 储存温度2-8℃ |
| 密度 | 1.3000 |
| 应用 | An effective inhibitor of CaMKII phosphorylating activity |
| 产品介绍 | KN-93是钙离子/钙调蛋白依赖激酶II（CaMKII）抑制剂，能竞争性阻断钙调蛋白与对应激酶的结合，Ki为370 nM。 |
| 生化机理 |
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell. |
| 别名 | KN 93；KN93；N-[2-[[[3-(4-氯苯基)-2-丙烯-1-基]甲基氨基]甲基]苯基]-N-(2-羟基乙基)-4-甲氧基苯磺酰胺;KN 93;KN93；N-[2-[[[3-(4-Chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide；N-[2-[N-(4-Chlorocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide |
