产品描述
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | GW3965 hydrochloride |
| 备注 | GW3965 is a potent, selective LXRagonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. |
| 生化机理 | GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively. |
| 别名 | ;N/A; GW3965 hydrochloride; 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride |
