产品描述
| 熔点 | 275°C(lit.) |
| 溶解性 |
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| 应用 | A high-affinity, selective glucocorticoid receptor agonist. |
| 产品介绍 | Fluticasone propionate 是一种合成的皮质类固醇，是Fluticasone的衍生物，用于治疗哮喘和过敏性鼻炎（花粉症）。 |
| 备注 | Fluticasone propionate (Flonase, Veramyst) is a synthetic corticosteroid which is derived from fluticasone used to treat asthma and allergic rhinitis (hay fever). |
| 生化机理 | Fluticasone propionate is a high affinity, selective glucocorticoid receptor (GR) agonist (Kd = 0.5 nM). Fluticasone propionate potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Fluticasone propionate is a lipophilic anti-inflammatory agent derived from flumethasone. |
| 别名 | 丙酸氟替卡松;氟替卡松丙酸酯;6,9-二氟-11羟基甲基氧代(氧代丙氧基)雄甾,二烯硫代羧酸-S-氟甲酯;(6α,11β,16α,17α)-6,9-二氟-11-羟-16-甲基-3-氧代-17-(1-氧代丙氧基)-雄甾-1,4-二烯-17-硫代羧酸 S-(氟甲基)酯;Flonase; Veramyst;(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester;S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate; |
