产品描述
| 溶解性 | Partly miscible in water. |
| 存贮条件 | 储存温度-20°C |
| 应用 | A potent and selective CysLT1 receptor antagonist. |
| 产品介绍 | Zafirlukast是一种白三烯受体拮抗剂(LTRA)，IC50为0.6μM,作用于CYP2C9，IC50为7.0 μM。 |
| 备注 | Zafirlukast is a leukotriene receptor antagonist (LTRA). (IC50=0.6μM, IC50=7.0 ?M for CYP2C9) |
| 生化机理 | Zafirlukast is a potent subtype specific cysteinyl leukotriene type 1 receptor (CysLT1) antagonist; antiasthmatic. The cysteinyl-leukotrienes (CysLTs), LTC4 and LTD4, are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, augment microvascular permeability, and are vasoconstrictors of coronary arteries. |
| 别名 | 扎鲁司特; 扎鲁斯特;N-[3-[[2-甲氧基-4-[[[(2-甲苯基)磺酰基]氨基]羰基]苯基]甲基]-1-甲基-1H-吲哚-5-基]氨基甲酸环戊酯; Accolate; Accoleit; Vanticon;Cyclopentyl N-[3-[[2-Methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamate;Cyclopentyl [3-[2-Methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl]-1-methyl-1H-indol-5-yl]carbamate;N-[3-[[2-Methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamic Acid Cyclopentyl Ester;[3-[2-Methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl]-1-methyl-1H-indol-5-yl]carbamic Acid Cyclopentyl Ester |
