产品描述
| 熔点 | 152-153 °C |
| 溶解性 | Soluble in DMSO (47 mg/ml at 25 °C), methanol, ethanol (47 mg/ml at 25 °C), DMF (~30 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (~0.5 mg/ml). |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A 5-LO (5-lipoxygenase) inhibitor. |
| 产品介绍 | Zileuton 是一种口服有效的5-脂氧合酶抑制剂，从而抑制白三烯（LTB 4，LTC 4，LTD 4和LTE 4）的形成 |
| 备注 | Zileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation. |
| 生化机理 | Zileuton is an orally active 5-LO (5-lipoxygenase) inhibitor that inhibits LTB4 synthesis (IC50 values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Zileuton inhibits antigen-induced contraction of tracheal strips in vitro (IC50 = 6 μM) and shows antiasthmatic activity in vivo. Zileuton also weakly inhibits CYP1A2 (Ki = 66 - 98 μM). |
| 别名 | 齐留通; N-羟基-N-(1-苯并噻吩-2-基-乙基)脲;(±)-N-hydroxy-N-(1-benzo[b]thien-2-ylethyl)urea;1-(1-Benzothiophen-2-ylethyl)-1-hydroxy-urea;Zyflo; A 64077; Abbott 64077; Griluto-CR; Leutrol |
