产品描述
| 溶解性 | DMSO |
| 存贮条件 | 储存温度2-8℃ |
| 产品介绍 | Ziprasidone(CP88059)是5-HT和多巴胺受体拮抗剂，具有抗精神病活性。 |
| 生化机理 |
Ziprasidone is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects in preclinical assays predictive of antipsychotic activity. Whereas Ziprasidone is a dopamine antagonist in vitro and in vivo, its most potent action is antagonism of 5-HT2A receptors, where its affinity is an order of magnitude greater than that observed for dopamine D2 sites. Additionally, Ziprasidone inhibits neuronal uptake of 5-HT and norepinephrine comparable to the antidepressant imipramine. Ziprasidone differs from other atypical antipsychotic drugs in several clinically important ways, although further experience is necessary to clarify the significance of these differences. |
| 别名 | 齐拉西酮; 齐哌西酮;5-(2-(4-(1,2-苯并异噻唑-3-基)-1-哌嗪基)乙基)-6-氯-1,3-二氢-2H-吲哚-2-酮;Geodon; CP 88059; CP-88059; CP88059;5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one |
