产品描述
| 溶解性 | Soluble in 1.1eq. NaOH (100 mM), DMSO (50 mM), methanol, and water (slightly). |
| 存贮条件 | 储存温度-20°C |
| 应用 | A RARα agonist that induces differentiation and apoptosis |
| 产品介绍 | Tamibarotene是特异性的RAR-alpha/beta激动剂, 用于治疗全反式视黄酸耐受的急性白血病。 |
| 生化机理 | AM 80 is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. AM 80 displays anticancer activity against acute promyelocytic leukemia in vitro and exhibits antiproliferative effects against a variety of tumor cell lines. |
| 别名 | 他米巴罗汀; 4-[(5,5,8,8-四甲基-6,7-二氢萘-2-基)氨基甲酰]苯甲酸;4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoicacid |
