产品描述
| 溶解性 | Soluble in DMSO (32 mg/ml at 25 °C), methanol, DMF (~21.6 mg/ml), ethanol (1.35 mg/ml, sonication), and water (slightly). |
| 存贮条件 | 储存温度2-8℃ |
| 产品介绍 | A77 1726, also known as teriflunomide, is the active metabolite of leflunomide. This compound has demonstrated antiinflammatory, antiproliferative, and immunosuppressive effects. A77 1726 has been shown to inhibit the proliferation of multiple mammalian cell lines in vitro, has demonstrated inhibition of Cox-2, dendritic cell function, DHODH (dihydroorotate dehydrogenase), and blocks TNF-dependent nuclear factor-κ B activation and gene expression. DHODH is an enzyme involved in the de novo synthesis of pyrimidine nucleotides, and its inhibition is thought to result in the antiproliferative effects on rapidly dividing cells, such as T-cells, observed by this compound. |
| 生化机理 | An active metabolite of leflunomide that inhibits Cox-2 |
| 别名 | 特立氟胺;SU 20;A 1726;A77-1726;A771726;Flucyamide;HMR 1726;(Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide;N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotoamide |
