产品描述
| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | OTX-015是新型BRD2/3/4抑制剂，对一些B细胞肿瘤细胞株有抗增殖活性，对DLBCL 细胞的IC50为192nM。 |
| 生化机理 |
OTX-015 is a new potent BRD-inhibitor with evident anti-proliferative activity in several cell lines representative of mature B-cell tumors. in vitro: OTX-015 demonstrated anti-proliferative activity in DLBCL cell lines (median IC50 0.192 uM). Similar results were obtained on SMZL (median IC50 0.165 uM), and on MM cell lines (median IC50 0.449 uM). MCL cell lines appeared less sensitive to OTX-015 (median IC50 2.01 uM). Among DLBCL cell lines, there was no difference based upon the cell of origin of the cell lines. OTX-105 caused a cell cycle arrest in G1 in a dose-dependent manner in 5/5 DLBCL and 3/3 MM cell lines, without an increase in cell death |
| 别名 | OTX 015;OTX-015;(S)-4-(4-氯苯基)-N-(4-羟基苯基)-2,3,9-三甲基-6H-噻吩并[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂卓-6-乙酰胺;OTX 015;OTX-015;(S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
