产品描述
| 溶解性 | DMSO ≥60mg/mL;Water <1.2mg/mL;Ethanol ≥60mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A steroid 17,20-lyase inhibitor with efficacy in rat, monkey, and human cells. |
| 产品介绍 | Orteronel(TAK-700)是已进入临床三期的用于治疗去势抵抗性前列腺癌的化合物。 |
| 生化机理 | TAK-700 shows potent inhibitory activity against rat, monkey, and human steroid 17,20-lyase inhibitor with IC50 of 54 nM, 27 nM, and 38 nM, respectively. In monkey adrenal cells, TAK-700 inhibits the ACTH stimulated production of DHEA and androstenedione with IC50 of 110 nM and 130 nM, respectively. TAK-700 also potently inhibits DHEA production in human adrenocortical tumor line H295R cells with IC50 of 37 nM. |
| 别名 | 6-[(7S)-7-羟基-6,7-二氢-5H-吡咯并[1,2-c]咪唑-7-基]-N-甲基-2-萘甲酰胺;TAK-700 (S-form);6-[(7S)-7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthalenecarboxamide |
