Montelukast sodium hydrate

Montelukast sodium hydrate

产品参数

货号 规格 操作
M129586-1g 咨询
M129586-200mg 咨询
M129586-5g 咨询
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服务地域:全国

属性:产地:上海; 品牌:阿拉丁 ;货期:现货

上海阿拉丁生化科技股份有限公司

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产品描述产品描述
  • 分子式 C35H35ClNO3S·Na · xH2O
  • 分子量608.17 (anhydrous basis)
  • Beilstein号
  • EC号
  • MDL号 MFCD00931431
  • PubChem编号

属性

旋光率 +95.0 to +105.0 deg(C=1、MeOH)
敏感性 对湿度敏感;对空气敏感;对光线敏感
溶解性
  • DMSO 100 mg/mL
  • Water 100 mg/mL
  • Ethanol 100 mg/mL
  • 存贮条件 储存温度2-8℃

    描述

    应用 Montelukast sodium hydrate is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is a subtype specific CysLT1 receptor antagonist.
    备注 Montelukast selectively antagonizes leukotriene D 4 (LTD4) by binding to it so that block the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1.
    生化机理

    Montelukast Sodium(Singulair) is a potent, selective, anti-inflammatory CysLT1 receptor antagonist (IC50 < 5nM) with no appreciable affect on the CysLT2 receptor. In rat colitis Montelukast Sodium (Singulair) has demonstrated the ability to increase PGE2 production and lower COX-2 expression. Inhibition is competitive with respect to leukotrienes - particularly LTD4, a biologically active mediator that plays an important role in the control of several biochemical pathways involving pulmonary and immune system function.

    别名 孟鲁司特钠 水合物;1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt hydrate
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