产品描述
| 熔点 | 166.5 °C |
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in DMSO (54 mg/ml at 25 °C), ethanol (54 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C). |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | An inhibitor of Cox-2 and tyrosine kinase. |
| 产品介绍 | Leflunomide是免疫抑制剂，其活性代谢产物为A77 1726(RS-61980)。 |
| 备注 | Leflunomide is an immunosuppressant agent. Its active metabolite is Teriflunomide. |
| 生化机理 | Leflunomide is an immunosuppressive drug that inhibits T and B cell responses. Leflunomide is an inhibitor of Cox-2, of tyrosine phosphorylation (tyrosine kinase), of DHODH (dihydroorotate dehydrogenase), an enzyme for de novo pyrimidine synthesis, and of TNF-dependent NF-κB activation. The physiological activity of leflunomide is attributed mainly to its metabolite A77 1726. |
| 别名 | 5-甲基-N-[4-(三氟甲基)苯基]异恶唑-4-甲酰胺;来氟米特;HWA486; RS-34821; SU101;5-Methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide;5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide;HWA486; RS-34821; SU101 |
