产品描述
| 溶解性 | Soluble in ethanol (5 mM), DMSO (100 mM), CHCl3/MeOH 1/1 (9.80-10.20 mg/ml), water (<1 mg/ml at 25° C), DMSO (64 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C). |
| 存贮条件 | 储存温度-20°C |
| 应用 | It elicits cell apoptosis and blocks CFTR Cl- channel |
| 产品介绍 | Lonidamine is an indazole compound that has been reported to inhibit angiogenic-related endothelial cell functions. This compound has been found to trigger apoptosis in endothelial cells and cause a decrease in proliferation, migration, invasion, and morphogenesis. The apoptotic effects of Lonidamine have been demonstrated to be due to Bax, Bid, caspase-3, and caspase-9 activation, as well as cytochrome c release. Futher studies show that Lonidamine prevents cellular energy metabolism via HXK (hexokinase) inhibition. This compound also blocks CFTR Cl- channels in vitro. |
| 备注 | Lonidamine is an orally administered small molecule hexokinase inactivator with an IC50 of 0.85 mM. |
| 生化机理 | 通过干扰己糖激酶和干扰非偶联刺激的线粒体电子传递来抑制肿瘤细胞的能量代谢；损伤细胞和线粒体膜 |
| 别名 | 氯尼达明;诺尼达明;1-(2,4-二氯苯基)-1H-吲唑-3-羧酸;1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid Diclondazolic acid |
