产品描述
| 溶解性 | Soluble in DMSO (10 mM) with gentle warming, water ( <1 mg/mL at 25 °C), and ethanol ( <1 mg/mL at 25 °C). |
| 存贮条件 | 储存温度-20°C |
| 应用 | A potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase |
| 产品介绍 | PD153035 HCl是一种有效的，特异性的EGFR抑制剂，Ki和IC50分别为5.2 pM和29 pM；对PGDFR， FGFR， CSF-1，InsR和Src几乎无作用。 |
| 备注 | PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src. |
| 生化机理 | PD 153035 Hydrochloride is an extremely potent inhibitor of EGFR (epidermal growth factor receptor) tyrosine kinase (IC50 = 25 pM). Only inhibits other purified tyrosine kinases at micromolar or higher concentrations. |
| 别名 | 4-[(3-溴苯基)氨基]-6,7-二甲氧基喹唑啉盐酸盐盐;4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride;AG 1517;PD 153035;SU 5271;ZM 252868 |
