肝原位模型通过将肝癌组织块直接在小鼠肝脏进行移植，建立肝癌原位模型，相对皮下成瘤模型，更加模拟肝癌的实际生长情况。

技术原理

先制备皮下成瘤模型，取出皮下肿瘤，切成小块；通过外科手术，将肿瘤块接种到动物肝脏上，制备肝原位移植模型，通过借助小动物活体成像仪器观察动物肝脏上肿瘤的形成、增殖以及体内转移灶的发生、发展情况，评价细胞的肝原位成瘤能力以及在动物体内的转移能力，主要适用于肝癌在体内原位成瘤和转移方向的研究。可提供的建模细胞系有：肝癌等。

结果展示

肝癌细胞感染携带有Luc的慢病毒，原位接种于4周龄裸小鼠肝脏，4周后，活体成像。可见裸鼠体内有肿瘤形成。

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