摘 要: 目的: 观察奥卡西平( OXC) 与卡马西平( CBZ) 对老年三叉神经痛( PTN) 患者血浆 P 物质( SP)
水平及睡眠质量的影响比较。方法: 按随机数表法将 142 例老年 PTN 患者分为 OXC 组( 研究组) 和 CBZ 组( 对照组) 各 71
例。于治疗前( T1) 、治疗 2 个月后( T2) 评估 2 组患者疼痛程度[简化 McGill 疼痛问卷-2( SF-MPQ-2)
]和睡眠质量[理查兹-坎贝尔睡眠量表( RCSQ) ],检测两组患者血浆 P 物质( SP) 、β-内啡肽( β-EP)
水平,观察不良反应情况。结果: T2 时,两组 SF-MPQ-2 和RCSQ 评分、血浆 SP 水平均较T1 时降低,且研究组低于对照组( P 均
< 0. 05) ;血浆 β-EP 水平则较 T1 时升高,且研究组高于对照组( P 均 < 0. 05) 。研究组不良反应发生率低于对照组(
P <
0. 05) 。结论: OXC 对老年 PTN 患者疼痛、睡眠改善情况优于 CBZ,且不良反应发生率较 CBZ 低,更具安全性。
关键词: 奥卡西平; 卡马西平; 三叉神经痛; 睡眠质量; 老年人
中图分类号: R745. 1 + 1 文献标志码: A 文章编号: 1001 - 5779( 2018) 06 - 0559 - 03
DOI: 10. 3969 / j. issn. 1001 - 5779. 2018. 06. 010
Effects
of oxcarbazepine and carbamazepine on plasma substance P level and
sleep quality in elderly patients with primary trigeminal neuralgia
GAO Chu,HAN Xiao
( Department of Neurology,Yongcheng People's Hospital,Yongcheng,Henan 476600)
Abstract:
Objective: To observe the effects of oxcarbazepine ( OXC) and
carbamazepine ( CBZ) on plasma substance P ( SP) level and sleep quality
in elderly patients with primary trigeminal neuralgia ( PTN) . Methods:
142 cases of elderly PTN patients were divided into OXC group ( study
group) and CBZ group ( control group) with 71 cases in each group ac-
cording to the random number table method. The pain degree [short-form
McGill Pain Questionnaire-2 ( SF-MPQ-2) ] and sleep quality
[Richards-Campbell Sleep Questionnaire ( RCSQ) ] were assessed in the
two groups before treatment ( T1) and after 2 months of treatment ( T2)
,and the levels of plasma substance P ( SP) and β-endorphin ( β-EP) were
measured in the two groups,and adverse reactions were observed.
Results: At T2,the scores of SF-MPQ-2 and RCSQ and the plasma SP level
in the two groups were lower than those at T1,and the indexes in study
group were lower than those in control group ( all P < 0. 05) . The
plasma β-EP level was higher than that at T1,and the level in study
group was higher than that in control group ( all P < 0. 05) . The
incidence rate of adverse reactions in study group was lower than that
in control group ( P < 0. 05) . Conclusions: OXC is superior to CBZ in
the improvement of pain and sleep in elderly PTN patients,and the
incidence rate of adverse reactions is lower than that of CBZ,and OXC
has higher safety. Key Words: Oxcarbazepine; Carbamazepine; Trigeminal
neuralgia; Sleep quality; Elderly
慢性顽固性三叉神经痛( TN)
具有反复、剧烈、突发、间歇期症状不显著等特点,原发性 TN( PTN) 常见于老年人群,发病率约为 4 ~ 5 /10
000。本病引起的剧烈疼痛不仅造成患者痛苦,还对其饮食、睡眠 等造成严重影响。奥卡西平( OXC ) 、卡 马西平
( CBZ) 均为治疗 PTN 的一线药物。文献显示,OXC使用时无需常规监测血药浓度,药物相互作用较少[1],可能较 CBZ 更具优势。对此,本研究观察 OXC、CBZ 在 PTN 中的应用情况,现报告如下。
* 作者简介: 高处,男,本科,主治医师,研究方向: 神经内科。