产品描述
| 溶解性 | Soluble in DMSO (25 mg/mL), ethanol (5 mg/mL warm), methanol, 0.1N HCI, and chloroform/methanol (9:1) (50 mg/mL). Insoluble in water, and dilute aqueous base.. |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A calcium channel protein inhibitor. |
| 产品介绍 | Flunarizine 2HCl是一种二氢盐酸盐，抑制钙离子通道，Ki为68 nM。 |
| 备注 | Flunarizine dihydrochloride is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM. |
| 生化机理 | Flunarizine ? 2HCl, a calcium channel protein inhibitor and antagonist, has been shown to inhibit contraction of isolated murine caudal artery preparations. Mechanistic studies suggest that this compound inhibits prostaglandin-induced and Serotonin ? HCl induced components of the contraction via reduction in the amounts of TXB2 (Thromboxane B2) and ALK-1, and an increase in production of HETE. Experiments on rabbit sino-atrial nodes and isolated guinea-pig papillary muscles have reported that Flunarizine ? 2HCl depressed the slow action potentials of K+-depolarized papillary muscle. Additionally, studies indicate that Flunarizine ? 2HCl selectively suppresses Ca2+ influx through the cell membrane of sino-atrial nodes. |
| 别名 | 盐酸氟桂利嗪; (E)-1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)-哌嗪二盐酸盐;1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)哌嗪 二盐酸盐;Sibelium;Flunarizine dihydrochloride;1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride |
