产品描述
| 溶解性 | Soluble in water (4 mg/ml), DMSO (>25 mg/ml), ethanol, ether, and methanol. |
| 应用 | A small molecule KATP (Kir6) channel opener and NO donor |
| 产品介绍 | Nicorandil 钾离子通道活化剂. |
| 备注 | Nicorandil is potassium channel activator. |
| 生化机理 | Nicorandil is a small molecule KATP (Kir6) channel opener, producing relaxation of coronary vascular smooth muscle. Specific binding of Nicorandil to the C-terminus of the SUR2B K(ATP) channel generates K+ flux and hyperpolarization of the surface membrane, producing consequent closure of voltage-dependent ion channels and reduction of intracellular free Ca2+. Nicorandil stimulates guanylate cyclase and increases cyclic GMP levels in correlation with the activation of K(ATP) channels. Nicorandil is also described to suppress mitochondrial permeability transition triggered by oxidative stress resulting from ischemia-reperfusion, preventing mitochondrial calcium uptake/overload and oxidative damage. Nicorandil has also been shown to serve as a nitric oxide donor. |
| 别名 | 尼可地尔;烟浪丁;硝烟酯;2-(吡啶基-3-甲酰胺)乙基硝酸盐;N-[2-(硝氧基)乙基]吡啶-3-甲酰胺;SG-75;Sigmart;Zynicor;Ikorel;2-(Pyridine-3-carbonylamino)ethyl nitrate;2-Nicotinamidoethyl nitrate;N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide |
