产品描述
| 溶解性 | Soluble in DMSO (105 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), and ethanol (6 mg/ml at 25 °C). |
| 应用 | An ATP-dependent K+ (KATP) channel blocker. |
| 产品介绍 | Gliquidone是一种ATP敏感的K+通道拮抗剂，IC50为27.2 nM |
| 备注 | Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| 生化机理 | Gliquidone is an ATP-dependent K+ (KATP) channel blocker. Gliquidone is an anti-diabetic drug in the sulfonylurea class. Gliquidone is used in the treatment of diabetes mellitus type 2. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release. |
| 别名 | 糖肾平;格列喹酮;3-环己基-1-[4-[2-(3,4-二氢-7-甲氧基-4,4-二甲基-1,3-双氧基-2-(1H)-异喹啉基)-乙基]苯基]磺酰基-脲;3-Cyclohexyl-1-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-isoquinolin-2-yl)ethyl]phenyl]sulfonyl-urea |
